2010年，华中科技大学，生命科学与技术学院，工学学士；

2015年，清华大学，生命科学学院，生物学博士（导师：施一公）；

2015-2017年，清华大学，基础医学院，博士后（导师：颜宁）；

2017-2018年，普林斯顿大学，分子生物学系，博士后（导师：颜宁）；

2018-2026年，南方科技大学，生命科学学院，PI/博导/研究员/副教授；

2026年2月至今，南昌大学，基础医学院/第二附属医院/生物医学创新研究院，PI/博导/教授。

  实验室长期致力于结构生物学与药物靶点研究，重点围绕脂质代谢关键蛋白的结构与功能展开系统解析，揭示脂质稳态维持的分子机制，并基于结构开展靶向干预研究，为相关疾病的治疗提供新策略。同时，课题组也关注其他重要药物靶点蛋白的结构机制，推动靶向药物的开发与机制探索。近年来以通讯作者或第一作者（含共同）在Cell（3篇）、Science、Cell Research（2篇）、Nature Structural & Molecular Biology、Nature Plants、Nature Communications（5篇）、Science Advances（2篇）、The EMBO Journal、Cell Reports、Structure等国际知名期刊发表多篇研究论文。

主要荣誉与项目资助：

• 国家自然科学基金青年科学基金项目（B类）

• 国家自然科学基金重大研究计划

• 广东省杰出青年科学基金

• 深圳市优秀青年科学基金

• 深圳市国家级领军人才

• 深圳市海外高层次人才

担任多个国际期刊的审稿人及国家自然科学基金委、教育部、科技部及多省市科研与人才项目的评审专家。

通讯或者第一作者（含共同）论文 (*,第一作者; #, 通讯作者)

1. Ma X*, Wang W*, Zhang J*, Jiang Z*, Xu C*, Zhu W, Shi B, Yang W, Su H, Wang X, Chen D, Wang Y, Wang J, Wang J, Liu X, Wang X, Huang X, Xie W, Cai Y, Xu K, Xin P, Liu L, Lü P, Wang Y, Chu J, Gong X#, Chu C#, Hu B#. NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants. Cell. 2025 Aug 7:S0092-8674(25)00816-5.

2. Wu X*, Gong X#, Xie T#. Mechanisms of aureobasidin A inhibition and drug resistance in a fungal IPC synthase complex. Nature Communications. 2025 May 30;16(1):5010.

3. Zhang Z*, Fang Q*, Xie T#, Gong X#. Mechanism of ceramide synthase inhibition by fumonisin B1. Structure. 2024 Sep 5; 32, 1-10.

4. Xie T*, Dong F*, Han G*, Wu X*, Liu P, Zhang Z, Zhong J, Niranjanakumari S, Gable K, Gupta SD, Liu W, Harrison PJ, Campopiano DJ, Dunn TM#, Gong X#. Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide. Cell Reports. 2024 Feb 27;43(2),113717.

5. Xie T*, Fang Q*, Zhang Z, Wang Y, Dong F, Gong X#. Structure and mechanism of a eukaryotic ceramide synthase complex. The EMBO Journal. 2023 Dec 11;42(24):e114889.

6. Xie T*, Liu P*, Wu X, Yue J, Dong F, Zhang Z, Mahawar U, Farooq F, Vohra H, Fang Q, Liu W, Wattenberg BW#, Gong X#. Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nature Communications. 2023 Jun 13;14(1):3475.

7. Liu P*, Xie T*, Wu X, Han G, Gupta SD, Zhang Z, Yue J, Dong F, Gable K, Niranjanakumari S, Li W, Wang L, Liu W, Yao R, Cahoon EB, Dunn TM, Gong X#. Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Science Advances. 2023 Mar 29;9(13):eadg0728.

8. Xie T*, Zhang Z*, Yue J*, Fang Q, Gong X#. Cryo-EM structures of the human surfactant lipid transporter ABCA3. Science Advances. 2022 Apr 8;8(14): eabn3727.

9. Li W*, Wang L*, Wierbowski BM*, Lu M, Dong F, Liu W, Li S, Wang P, Salic A#, Gong X#. Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nature Communications. 2021 Nov 29;12(1):6966.

10. Xie T*, Zhang Z*, Fang Q, Du B, Gong X#. Structural basis of substrate recognition and translocation by human ABCA4. Nature Communications. 2021 Jun 22;12(1):3853.

11. Li S*, Xie T*, Liu P*, Wang L, Gong X#. Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex. Nature Structural & Molecular Biology. 2021 Mar;28(3):249-257.

12. Ma L*, Guan Z, Wang Q, Yan X, Wang J, Wang J, Cao J, Zhang D, Gong X#, Yin P#. Structural insights into the photoactivation of Arabidopsis CRY2. Nature Plants. 2020 Nov 16;6(12):1432-1438.

13. Qian H*, Cao P*, Hu M, Gao S, Yan N#, Gong X#. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nature Communications. 2019 May 24;10(1):2320.

14. Qian H*, Zhao X, Cao P, Lei J, Yan N#, Gong X*,#. Structure of the human lipid exporter ABCA1. Cell. 2017 Jun 15;169(7):1228–1239.

15. Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N#. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402).

16. Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu J, Li W, Wang H, Espenshade PJ#, Yan N#. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Research. 2016 Nov;26(11):1197-1211.

17. Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q#, Yan N#. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. 2016 Jun 2;165(6):1467-78.

18. Gong X*, Li J*, Shao W*, Wu J, Qian H, Ren R, Espenshade PJ#, Yan N#. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research. 2015 Apr;25(4):401-11.

E-mail: gongx@ncu.edu.cn