刘卓琦 博士

副教授

2001年，江西医学院, 临床医学，医学学士；

2006年，南昌大学, 生物化学与分子生物学, 硕士

2016年，南昌大学, 内科学, 博士

课题组专注于肿瘤表观遗传学的前沿研究，以临床疾病诊治过程中的关键问题为研究靶向，利用生物信息学技术对高通量数据进行深入挖掘，寻找应用于临床诊疗的疾病分子标志物,为精准医疗提供了新方向。

目前，课题组的研究方向主要包括以下几个核心领域：

1. 肿瘤转移分子标志物的筛选：识别与肿瘤侵袭和转移过程密切相关的分子靶点；

2. 疾病相关基因的表观遗传学修饰：研究基因表达调控中的表观遗传学变化，探讨其在疾病发生发展中的临床意义；

3. 肿瘤代谢重编程：解析肿瘤细胞如何通过代谢途径的调整来适应快速增殖的需求，以及肿瘤代谢物对肿瘤进展的作用；

4. 个性化诊疗策略的探索：基于个体基因组和表观基因组的特征，开发个性化的疾病预防、诊断和治疗方案。

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近五年发表的代表性论著

(1) Xiong S, Zhu W, Wu L, Zhou T, Wang W, Zhang O, Xiong X, Liu Z, Luo D. Circadian pattern subtyping unveiling distinct immune landscapes in breast cancer patients for better immunotherapy. Cancer Immunol Immunother. 2023 Oct;72(10):3293-3307.

(2) Chao Wang; Minghua Cao; Xiaoli Jiang; Yudi Yao; Zhuoqi Liu; Daya Luo ; Macrophage balance fraction determines the degree of immunosuppression and metastatic ability of breast cancer, International Immunopharmacology, 2021, 97 (期刊论文)

(3) Chunwan Lu; Zhuoqi Liu; John D Klement; Dafeng Yang; Alyssa D Merting; Dakota Poschel; Thomas Albers; Jennifer L Waller; Huidong Shi; Kebin Liu ; WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape, Journal Immunother Cancer, 2021.9, 2021(9) (期刊论文)

(4) Ding ZC, Shi H, Aboelella NS, Fesenkova K, Park EJ, Liu Z, Pei L, Li J, McIndoe RA, Xu H, Piazza GA, Blazar BR, Munn DH, Zhou G. Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunity. Sci Immunol. 2020 Oct 30;5(52):eaba5962.

(5) Smith AD, Lu C, Payne D, Paschall AV, Klement JD, Redd PS, Ibrahim ML, Yang D, Han Q, Liu Z, Shi H, Hartney TJ, Nayak-Kapoor A, Liu K. Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells. Cancer Res. 2020 Aug 1;80(15):3145-3156. doi: 10.1158/0008-5472.CAN-19-3670

(6) Qiang Liu; Hongfei Zhang; Xiaoli Jiang; Caiyun Qian; Zhuoqi Liu; Daya Luo ; Factors involved in cancer metastasis: a better understanding to “seed and soil” hypothesis, Molecular Cancer, 2017, 16(176) (期刊论文)

(7) Ping Wang; Jiaxuan Liu; Yunlei Song; Qiang Liu; Chao Wang; Caiyun Qian; Shuhua Zhang; Weifeng Zhu; Xiaohong Yang; Fusheng Wan; Zhuoqi Liu; Daya Luo ; Screening of immunosuppressive factors for biomarkers of breast cancer malignancy phenotypes and subtype-specific targeted therapy, PeerJ, 2019, 7: 0-e7197 (期刊论文)

E-mail: liuzhuoqi@ncu.edu.cn