余华 博士

特聘教授、博士生导师

非编码RNA功能研究与转化应用实验室独立PI

医学科技创新中心组学与大数据平台负责人

教育和工作背景:

2010年，安徽科技学院，生物技术专业，理学学士；

2013年，西北农林科技大学，生物信息学专业，理学硕士；

2017年，中国科学院遗传与发育生物学研究所，生物信息学专业，理学博士；

2017/08—2018/03，南通大学医学院，讲师；

2018/04—2021/06，浙江大学医学院，博士后；

2021/09—2022/11，西湖大学生命科学学院，助理研究员；

2022/12—2023/02，西湖实验室，副研究员；

2022/03—至今，南昌大学基础医学院，特聘教授、博士生导师。

研究兴趣及领域：

课题组长期致力于通过干湿相结合的研究策略（一方面开发新型计算生物学方法及工具，另一方面开展生物学实验）对非编码RNA功能及作用机制进行系统性研究及应用转化，发现驱动胚胎干细胞命运决定及癌症发生发展的关键非编码RNA分子，筛选靶向关键非编码RNA的小分子及大分子药物。近年来，课题组在Nature Communications、Nature Metabolism、Protein & Cell、Genome Biology、Bioinformatics等高水平杂志上共发表SCI学术论文22篇，开发生物信息学软件7款，其中第一作者或通讯作者（含共同）论文14篇，发表当年影响因子累计197，全部文章累计被引用2200余次，H指数13，第一作者论文单篇最高引用次数351，代表性研究成果受邀在国际干细胞协会年会（ISSCR）上做口头学术报告，其中两篇论文被选为杂志封面论文，一篇论文被ScienceNews等多家知名媒体专题报道。

学术兼职：

Bioinformatics杂志审稿人。

代表性论文：

(#) 共同第一作者; (*) 通讯作者

[1]Hua Yu#, Zhen Sun#, Tianyu Tan#, Hongru Pan#, Jing Zhao, Ling Zhang, Jiayu Chen, Yuqing Zhu, Lang Chen, Yuyan Xu, Shaorong Gao, George Q. Daley, Jin Zhang*. rRNA Biogenesis Regulates Mouse2C-like State by 3D Structure ReorganizationofPeri-Nucleolar Heterochromatin. Nature Communications,2021 12(6365). https://doi.org/10.1038/s41467-021-26576-2.

[2] Zhen Sun#, Hua Yu#, Jing Zhao#, Tianyu Tan, Hongru Pan, Bo Gao, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Cristina Correia, Ming Chen, Qiming Sun, Li Shen, Longfei Wang, Yu Feng, Jianlong Wang, Xiaohua Shen, Hu Li, Hao Wu, George Q. Daley, Jin Zhang*. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein&Cell, 2021.https://doi.org/10.1007/s13238-021-00864-5.

[3] Jing Zhao#, Ke Yao#, Hua Yu#, Ling Zhang, Yuyan Xu, Lang Chen1, Zhen Sun, Yuqing Zhu, Chen Zhang, Yuli Qian, Zhuyan Ji, Min Zhang, Jie Chen, Cristina Correia, Taylor Weiskittel, Dan Zhang, Hu Li, Wei Xie, Zeping Hu*, Jin Zhang* Metabolic reprogramming during mouse early embryodevelopment. Nature Metabolism，2021 3(1).https://doi.org/10.1038/s42255-021-00464-x.

[4] Lin Yang, Yuqing Zhu#, Hua Yu#, Xiaolong Cheng, Sitong Chen, Yulan Chu, He Huang, Jin Zhang*, Wei Li*. scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Genome Biology, 2020 21(19). https://doi.org/10.1186/s13059-020-1928-4.

[5]Li Zhang#, Lin Tian#, Xiaoyang Dai#, Hua Yu#, Jiajia Wang#, Anhua Lei, Mengmeng Zhu, Jianpo Xu, Wei Zhao, Yuqing Zhu, Zhen Sun, Hao Zhang, Yongxian Hu, Yanlin Wang, Yuming Xu, George M. Church, He Huang, Qinjie Weng*,Jin Zhang*. Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions. Journal of Hematology and Oncology, 2020 13(153). https://doi.org/10.1186/s13045-020-00983-2.

[6] Hua Yu#*, Lu Lu#, Bingke Jiao, Chengzhi Liang*. Systematic discovery of novel and valuable plant gene modules by large-scale RNA-seq samples. Bioinformatics, 2018, bty642. https://doi.org/10.1093/bioinformatics/bty642.

[7]Hua Yu*, Biaoke Jiao, Lu Lu, Pengfei Wang, Shuangcheng Chen, Chengzhi Liang*, Wei Liu*, NetMiner-an ensemble pipeline for building genome-wide and high-quality gene co-expression network using massive-scale RNA-seq samples. PLoS ONE, 2018, 13(2): e019261.https://doi.org/10.1371/journal.pone.0192613.

[8] Hua Yu#*, Lu Lu#, Ming Chen, Chen Li*, Jin Zhang*, Genome-wide discovery of hidden genes mediating known drug-disease association usingKDDANet. npj Genomic Medicine, 2021 6(50). https://doi.org/10.1038/s41525-021-00216-6.

[9]Hua Yu#, Jianxin Chen#, Xue Xu, Yan Li, Huihui Zhao, Xiuxiu Li, Wei Zhou, Wei Wang* and Yonghua Wang*. A systematic prediction of multiple drug-target interactions from chemical, genomic and pharmacological data. PLoS ONE, 2012, 7(5): e37608. https://doi.org/10.1371/journal.pone.0037608.

[10] Hua Yu#*, Xiaojun Chen#*, Lu Lu. Large-scale prediction of microRNA-disease associations by combinatorial prioritization algorithm. Scientific Reports, 2017, 7:43792. https://doi.org/10.1038/srep43792.

[11] Lu Lu#, Jiale Qin#, Jiandong Chen, Hao Wu, Qiang Zhao, Satoru Miyano, Yaozhong Zhang*, Hua Yu* and Chen Li*. DDIT: An Online Predictor for Multiple Clinical Phenotypic Drug-Disease Associations. Frontier in Pharmacology, 2022, 12:772026. https://doi.org/10.3389/fphar.2021.772026

[12] Lu Lu*, Hua Yu*. DR2DI: a powerful computational tool for predicting novel drug-disease associations. Journal of Computer-Aided Molecular Design (2018) 32: 633. https://doi.org/10.1007/s10822-018-0117-y.

[13] Lingtong Liu#, Yunlong Lu#, Liqin Wei#, Hua Yu#, Yinghao Cao, Yan Li, Ning Yang, Yunyun Song, Chengzhi Liang*, Tai Wang*, Transcriptomics analyses reveal the molecular roadmap and long noncoding RNA landscape of sperm cell lineage development. The Plant Journal, 2018, 96(2):421-437. https://doi.org/10.1111/tpj.14041.

[14] Chengzhen Liang#, Aifu Li#, Hua Yu#, Wenzhen Li, Chengzhi Liang, Sandui Guo, Rui Zhang, Chengcai Chu. Melatonin Regulates Root Architecture by Modulating Auxin Response in Rice. Frontier in Plant Science, 2017, 8:134. https://doi.org/10.3389/fpls.2017.00134.

[15)] Hong-Qing Ling#*, Bin Ma#, Xiaoli Shi#, Hui Liu#, Lingli Dong#, Hua Sun#, Yinghao Cao, Qiang Gao, Shusong Zheng, Ye Li, Ying Yu, Huilong Du, Ming Qi, Yan Li, Hongwei Lu, Hua Yu, Yan Cui, Ning Wang, Chunlin Chen, Huilan Wu, Yan Zhao, Juncheng Zhang, Yiwen Li, Wenjuan Zhou, Bairu Zhang, Weijuan Hu, Michiel J. T. van Eijk, Jifeng Tang, Hanneke M. A. Witsenboer, Shancen Zhao, Zhensheng Li, Aimin Zhang*, Daowen Wang*, Chengzhi Liang*. Genome sequence of the progenitor of wheat A subgenome Triticum Urartu. Nature, 2018, 557:424-428. https://doi.org/10.1038/s41586-018-0108-0.

[16] Li Chen#, Qiaoqiao Tong#, Xiaowen Chen#, Penglei Jiang, Hua Yu, Qianbing Zhao, Lingang Sun, Chao Liu, Bin Gu, Yuping Zheng, Lijiang Fei, Xiao Jiang, Wenjuan Li, Giacomo Volpe, Mazid MD. Abdul, Guoji Guo, Jin Zhang, Pengxu Qian, Qiming Sun, Dante Neculai, Miguel A. Esteban, Chen Li, Feiqiu Wen, Junfeng Ji. PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus. Nature Communications, 2021, 12: 2829. https://doi.org/10.1038/s41467-021-22871-0.

[17] Lu Su#, Linkang Zhou#, Feng-Jung Chen, Huimin Wang, Hui Qian, Yuanyuan Sheng, Yuangang Zhu, Hua Yu, Xinqi Gong, Lie Cai, Xuerui Yang, Li Xu, Tong-Jin Zhao, John Zhong Li, Xiao-Wei Chen*, Peng Li*. Cideb controls sterol-regulated ER export of SREBP/ SCAP by promoting cargo loading at ER exit sites. The EMBO Journal, 2019, 38(8):e100156. https://doi.org/10.15252/embj.2018100156.

[18] Xue Li#, Xin Guo#, Yuqing Zhu#, Guoqing Wei, Yanlei Zhang, Xia Li, Huijun Xu, Jiazhen Cui, Wenjun Wu, Jingsong He, Matthew E.Ritchie, M.Weiskittel, Hu Li, Hua Yu, Lijuan Ding, Mi Shao, Qian Luo, XiaoxiaoXu, Xinyi Teng, Alex H.Chang, Jin Zhang*, He Huang*, Yongxian Hu*, Single cell transcriptomic analysis reveals BCMA CAR-T cell dynamics in a patient with refractory primary plasma cell leukemia. Molecular Therapy, 2021, 29(2):645-657. https://doi.org/10.1016/j.ymthe.2020.11.028.

荣誉及奖励

西湖实验室“开拓学者”计划入选者。

浙江大学优秀博士后。

西北农林科技大学优秀硕士学位论文。

联系方式：

E-mail: huayu@ncu.edu.cn