Dr. Yang Lei, Ph.D

Education

 2010.08-2014.08: Ph.D. in Biomedical Engineering, Clemson University

 2008.09-2010.06: M.S. in Materials Science and Engineering, Beihang University

 2004.09-2008.06: B.S. in Materials Science and Engineering, Nanjing University of Aeronautics and Astronautics

Professional Experience

 2024.07-Present: Researcher, Nanchang University / The First Affiliated Hospital of Nanchang University

 2016.03-2024.06: Associate Researcher, Sichuan University

 2014.08-2016.02: Postdoctoral Research Fellow, Harvard Medical School

Research Interests

My research focuses on application-oriented chemically crosslinked biomedical materials, covering bioprosthetic heart valve leaflet materials derived from animal pericardium, human amniotic membrane biomaterials, medical adhesives, injectable hydrogels and microspheres, antibody conjugation reagents, and cell purification kits.

1) Bioprosthetic heart valve leaflet materials

(Crosslinking mechanisms and novel crosslinking strategies for leaflet materials; biovalve leaflets polymerized and crosslinked with functional monomers; anti-calcification and anticoagulant technologies together with their underlying mechanisms; dry-state leaflet materials; low-immunogenicity bioprosthetic valve materials; synthetic polymer leaflet materials)

2) Human amniotic membrane biomaterials

(Dry preservation technology; innovative crosslinking methods for amniotic membranes; injectable amniotic membrane powder for osteoarthritis treatment)

3) Medical adhesives

(Solid medical pressure-sensitive adhesives; powder-type medical adhesives)

4) Collagen-based biomedical materials

(Research on the application of animal-derived collagen raw materials in biomedical devices and cosmetics)

Academic Affiliations

1) Young Editorial Board Member, Journal of Leather Science and Engineering, 2022-Present

2) Young Editorial Board Member, Cardiology Plus, 2025-Present

3) Invited Reviewer for journals including Advanced Science, Acta Biomaterialia, Advanced Healthcare Materials, Journal of Materials Chemistry B, Frontiers in Bioengineering and Biotechnology, and Journal of Leather Science and Engineering;

Academic Papers

1. Yue’e Wang, Liyang Cao, Haina He, Arooj Khabbir, Chun Hu, Renping Liu, Yang Lei*. Improved mechanical performance and enzymatic stability of crosslinked dry amniotic membrane by spraying. Collagen and Leather. 8,17(2026).

2. Cheng Zheng, Kailei Ding, Xueyu Huang, Li Yang, Yang Lei* and Yunbing Wang. A bioprosthetic heart valve prepared by copolymerization of 2-isocyanatoethyl methacrylate modified pericardium and functional monomer. Composites Part B: Engineering. 2022, 238, 109922.

3. Gaoyang Guo, Linhe Jin, Binggang Wu, Haiyang He, Fan Yang, Liangpeng Xu, Yang Lei*, Yunbing Wang*. A method for simultaneously crosslinking and functionalizing extracellular matrix-based biomaterials as bioprosthetic heart valves with enhanced endothelialization and reduced inflammation. Acta Biomaterialia. 2021, 119, 89-100.

4. Yang Lei, Nasim Nosoudi, and Naren Vyavahare*. Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects. Journal of Controlled Release. 2014, 196:79-86.

5. Yang Lei#, Xiaorong Lan#, Zhoukun He*, Anlin Yin, Wanyu Jin, Qinsheng Hu, Yunbing Wang*. Multifarious anti-biofouling bioprosthetic heart valve materials with the formation of interpenetrating polymer network structures. Materials & Design. 2021, 206, 109803.

Patents

1. NHS-activated lysine-agarose gel microspheres, preparation method and application thereof (Patent No.: 202511678408.9)

2. An Endothelialized Biological Heart Valve and Its Preparation Method (Patent No.: 202010040644.9)

3. A Non-Glutaraldehyde Preloadable Dry Biological Valve Material and Its Preparation Method (Patent No.: 202010097281.2)

4. A Dry Artificial Biological Heart Valve Containing Endothelialization-Promoting Peptides and Its Preparation Method (Patent No.: 201910408742.0)

5. A Crosslinking Treatment Method for Improving Elastin Stability of Biological Valves (Patent No.: 201811128254.6)