Dr. Hua Yu, Ph.D

Distinguished Professor

Jiangxi Medical College, Nanchang University

huayu@ncu.edu.cn

Education

2006 – 2010: B.Sc. in Biotechnology, Anhui Science and Technology University

2010 – 2013: M.Sc. in Bioinformatics, Northwest A&F University

2013 – 2017: Ph.D. in Bioinformatics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

Professional Experiences

Aug 2017 – Mar 2018: Lecturer, School of Medicine, Nantong University

Apr 2018 – Jun 2021: Postdoctoral Fellow, School of Medicine, Zhejiang University

Sep 2021 – Nov 2022: Assistant Research Fellow, School of Life Sciences, Westlake University

Dec 2022 – Feb 2023: Associate Research Fellow, Westlake Laboratory

Mar 2022 – Present: Distinguished Professor, Jiangxi Medical College, Nanchang University

Research Interests

The mission of our group is to elucidate the functions and mechanisms of non-coding RNA in totipotent stem cells and human cancers by combining both dry and wet research strategies. On the one hand, our group will develop novel computational software to systematically predict and infer the functions of non-coding RNAs and phenotype-related non-coding RNAs. On the other hand, we will carry out biological experiments to discover key non-coding RNAs driving the fate transition of totipotent stem cells and the occurrence and development of human cancers, and further screening potential drugs targeting key non-coding RNAs.

Review Activities

Nature Communications, Science Bulletin, Bioinformatics

Selected Publications

(#) Co-first author; (*) Corresponding author

Hua Yu#*, Jing Zhao#, Yuxuan Shen, Qiao Lu, Yuheng Liu, Guanglei Xie, Shuhui Chang, Tingying Ge, Nan Li, Ming Chen, Hu Li, Jin Zhang*, Xi Wang*. The dynamic landscape of enhancer-derived RNA during mammalian early embryo development. Cell Reports, 2024, 43(4):114077.

Hua Yu#, Zhen Sun#, Tianyu Tan#, Hongru Pan#, Jing Zhao, Ling Zhang, Jiayu Chen, Yuqing Zhu, Lang Chen, Yuyan Xu, Shaorong Gao, George Q. Daley, Jin Zhang*. rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin. Nature Communications, 2021 12(6365).

Anhua Lei#, Hua Yu#, Shan Lu, Hengxing Lu, Xizhong Ding, Tianyu Tan, Hailing Zhang, Mengmeng Zhu, Lin Tian, Xudong Wang, Siyu Su, Dixuan Xue, Shaolong Zhang, Wei Zhao, Yuge Chen, Wanrun Xie, Li Zhang, Yuqing Zhu, Jing Zhao, Wenhong Jiang, George Church, Francis Ka-Ming Chan, Zhihua Gao, Jin Zhang*. A second generation M1-polarized CAR macrophage with antitumor efficacy. Nature Immunology, 2023, 25:102-116.

Zhen Sun#, Hua Yu#, Jing Zhao#, Tianyu Tan, Hongru Pan, Bo Gao, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Cristina Correia, Ming Chen, Qiming Sun, Li Shen, Longfei Wang, Yu Feng, Jianlong Wang, Xiaohua Shen, Hu Li, Hao Wu, George Q. Daley, Jin Zhang*. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell, 2021, 13:490-512.

Jing Zhao#, Ke Yao#, Hua Yu#, Ling Zhang, Yuyan Xu, Lang Chen1, Zhen Sun, Yuqing Zhu, Chen Zhang, Yuli Qian, Zhuyan Ji, Min Zhang, Jie Chen, Cristina Correia, Taylor Weiskittel, Dan Zhang, Hu Li, Wei Xie, Zeping Hu*, Jin Zhang* Metabolic reprogramming during mouse early embryo development. Nature Metabolism, 2021, 3:1372-1384.

Lin Yang, Yuqing Zhu#, Hua Yu#, Xiaolong Cheng, Sitong Chen, Yulan Chu, He Huang, Jin Zhang*, Wei Li*. scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Genome Biology, 2020 21(1):19.

Li Zhang#, Lin Tian#, Xiaoyang Dai#, Hua Yu#, Jiajia Wang#, Anhua Lei, Mengmeng Zhu, Jianpo Xu, Wei Zhao, Yuqing Zhu, Zhen Sun, Hao Zhang, Yongxian Hu, Yanlin Wang, Yuming Xu, George M. Church, He Huang, Qinjie Weng*, Jin Zhang*. Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions. Journal of Hematology and Oncology, 2020, 13(1):153.

Hua Yu#*, Lu Lu#, Bingke Jiao, Chengzhi Liang*. Systematic discovery of novel and valuable plant gene modules by large-scale RNA-seq samples. Bioinformatics, 2019, 35(3):361-364.