• Jul. 2017 – Present: Professor, School of Basic Medical Sciences, Nanchang University

• 2014 – 2017: Postdoctoral Research Fellow, Harvard Medical School

• 2012 – 2014: Postdoctoral Research Fellow, Department of Biochemistry and Molecular Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

• 2012: Doctor of Science in Biophysics, Nagoya University, Japan

• 2008: Master of Science in Marine Biology, Dalian Ocean University

• 2004: Bachelor of Science in Biological Science, Nanchang University

Dr. Zhang Jin is a professor, holding a Doctor of Science degree from Nagoya University, Japan, and completing postdoctoral training at Harvard Medical School and Shanghai Institute of Materia Medica, CAS. His research group focuses on structural biology of membrane protein drug targets linked to major human diseases, as well as AI-based structure-guided targeted drug discovery. Targeting neuropsychiatric disorders, cardiovascular diseases, tumors and chronic illnesses that severely threaten public health in China, his team develops novel therapeutics leveraging artificial intelligence and 3D structures of ion channels. As first author or corresponding author (including co-corresponding), he has published numerous high-impact research papers in top international journals, including Science (cover article), two Nature papers, Neuron, two Cell Research, two PNAS, two Science Advances, two Nature Communications, and Science Bulletin.

1. Peng Q, Li J, Jiang H, Cheng X, Nag P, Kleinau G, Lamb TD, Busche L, Lu Q, Zhou S, Liu Y, Zhang Y, Lv S, Wan S, Yang T, Chen Y, Zhang W, Nan W, Fu Y, Che T, Li Y, Liao H, Duan J, Schapiro I, Scheerer P, Zhang J. Cryo‑electron microscopy structures of human cone visual pigments. Science, 2026, 392: eadz8141. (Cover Article, Corresponding Author)

2. Yang T, Che T, Guo H, Cheng X, Wang M, Lv S, Yang X, Wu X, Liu Y, Liu H, Hu H, Li W, Wan S, Peng H, Nan W, Zhang Y, Zeng B, Neher E, Liu O, Yu B, Li F, Li G, Li J, Duan J, Zhang J. Cryo‑EM Structure Enabling Virtual Screening for the Discovery of Highly Potent TRPM3 Antagonists with Analgesic Efficacy. Neuron, 2026. （Corresponding Author）

3. Cheng X, Wan S, Jiang D, Zhang H, Hu B, Che T, Chen Y, Nan W, Zhou Z, Xiao C, Zhong L, Zhang Y, Xiong B, Hou P, Zhang J. Structural basis of the neuronal M‑current generated by an asymmetric KCNQ2/3 assembly. Cell Research, 2026. （Corresponding Author）

4. Chen Y, Che T, Cheng X, Yang X, Song X, Li J, Fu Y, Zhang W, Lv S, Yang T, Peng Q, Nan W, Wan S, Hua Y, Wu X, Hu H, Zhang Y, Liu Y, Yang M, Zeng S, Liu O, Yu B, Duan J, Li J, Xiong B, Zhang J. Cryo‑EM Structure of the TRPC1/5 Heteromer Enables Design of Antidepressant and Anxiolytic Drug with Reduced Side Effects. Nature Communications, 2026. （Corresponding Author）

5. Cheng X, Zhang W, Che T, Guo H, Nan W, Zhang Y, Fu Y, Wan S, Zhang J. Cryo‑EM structures of human P2X2/3 heteromer channel reveal the structural basis of ligand selectivity. Science Advances, 2026.（Corresponding Author）

6. Zhong L, Lin X, Cheng X, Wan S, Hua Y, Nan W, Hu B, Peng X, Zhou Z, Zhang Q, Yang H, Noé F, Yan Z, Jiang D, Zhang H, Liu F, Xiao C, Zhou Z, Mou Y, Yu H, Ma L, Huang C, Wong VKW, Chung SK, Shen B, Jiang ZH, Neher E, Zhu W, Zhang J, Hou P. Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1‑KCNE1 channel gating. Cell Research, 2025, 35(11): 887-899. （Co-Corresponding Author）

7. Che T, Chen Y, Cheng X, Hu H, Wu X, Zhang Y, Yang X, Liu Y, Liu H, Nan W, Wan S, Yang M, Zeng B, Li J, Zhang J, Xiong B. Structure‑guided design of picomolar‑level macrocyclic TRPC5 channel inhibitors with antidepressant activity. Acta Pharm Sin B, 2026, 16(1): 371-386. （Co-Corresponding Author）

8. Li J, Zhou X, Zhang Y, Zhong F, Lin C, McCormick PJ, Jiang F, Luo J, Zhou H, Wang Q, Fu Y, Duan J, Zhang J. Crystal structure of SARS‑CoV‑2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode. Science Bulletin, 2021, 66(7): 661-663. （Corresponding Author）

9. Duan J, Li J, Chen GL, Peng X, Zhang Y, Wang JB, Clapham DE, Zeng B, Li Z, Zhang J. Cryo‑EM structure of TRPC5 at 2.8 Å resolution reveals unique and conserved structural elements essential for channel function. Science Advances, 2019, 5: eaaw7935. （Corresponding Author）

10. Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang JB, Clapham DE, Li Z, Zhang J. Structure of the mouse TRPC4 ion channel. Nature Communications, 2018, 9: 3102. （Corresponding Author）

11. Duan J, Li Z, Li J, Hulse R, Santa-Cruz A, Valinsky W, Abiria S, Krapivinsky G, Zhang J, Clapham DE. Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(35): E8201-E8210. （Co-Corresponding Author）

12. Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE. Structure of full‑length human TRPM4. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115: 2377-2382. （Co-Corresponding Author）

13. Zhang J, Zhang K, Gao ZG, Paoletta S, Zhang D, Han GW, Li T, Ma L, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q. Agonist‑bound structure of the human P2Y12 receptor. Nature, 2014, 509: 119-122.（First Author）

14. Zhang K, Zhang J, Gao ZG, Zhang D, Zhu L, Han GW, Moss SM, Paoletta S, Kiselev E, Lu W. Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature, 2014, 509: 115-118.（Co-First Author）

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