Dr. Ye-Hua Li, Ph.D.

Distinguished Research Fellow of Nanchang University

liyehua@ncu.edu.cn

Education

 2012.08-2018.06, Ph.D. Student, School of Life Sciences, Tsinghua University, China

 2008.09-2012.06, B.Sc., School of Life Sciences, Tsinghua University, China

Professional Experiences

 2024.09-present: Research Fellow, Institute of Biomedical Innovation, Nanchang University, China

 2018.06-2024.09: Postdoc, National Institute of Biological Sciences, Beijing, China

Research Interests:

The laboratory is conducting in-depth research into the regulation and role of copper-mediated cell death using colorectal cancer cells and organoids. The aim is not only to elucidate the underlying molecular mechanisms, but also to examine how this process ‘interacts’ with other pathways, such as ferrocytosis, and how the tumour microenvironment influences this process. Ultimately, we hope to translate these fundamental findings into new combination therapy strategies and biomarkers, thereby providing new insights for the precision treatment of colorectal cancer.

Selected Publications

1、 Li, Yehua; Ma, Jiahao; Wang, Rui; Luo, Yuanhanyu; Zheng, Sanduo; Wang, Xiaodong; Zinc transporter 1 functions in copper uptake and cuproptosis, Cell Metabolism, 2024, 36(9): 2118-2129

2、 Li, Yehua; Xiaodan Wang; Meimei Huang; Xu Wang; Chunlin Li; Siqi Li; Yuhui Tang; Shicheng Yu; Yalong Wang; Wanglu Song; Wei Wu; Yuan Liu; Ye-Guang Chen; BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells, The EMBO Journal, 2024,43(23): 6032-6051

3、 Li, Yehua; Wang, Xiaodong;A metabolic perspective on cuproptosis. Trends in Endocrinology & Metabolism, 2025 Jul 17:S1043-2760(25)00144-4.

4、 Li, Yehua; Wang, Jiawen; Wang, Rui; Wang, Xiaodong; Gut bacteria induce IgA expression in pituitary hormone-secreting cells during aging, iScience, 2023, 26(10):107747

5、 Wang, Shan; Li, Siqi; Li, Yehua; Jiang, Quanlong; Li, Xintong; Wang, Yalong; Han, Jing-Dong; Liu, Yuan; Chen, Ye-Guang; Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation, Stem Cell Reports, 2021, 16(5): 1290-1301

6、 Li, Yehua; Liu, Yuan; Liu, Bofeng; Wang, Jilian; Wei, Siting; Qi, Zhen; Wang, Shan; Fu, Wei; Chen, Ye-Guang; A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5(+) intestinal stem cell maintenance, Cell Discovery, 2018, 4(4): 49-49

7、 Qi, Zhen; Li, Yehua; Zhao, Bing; Xu, Chi; Liu, Yuan; Li, Haonan; Zhang, Bingjie; Wang, Xinquan; Yang, Xiao; Xie, Wei; Li, Baojie; Han, Jing-Dong Jackie; Chen, Ye-Guang; BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes, Nature Communications, 2017, 8(8): 13824-13824

8、 Wu, Ye; Li, YeHua; Li, Xiang*; Zou, Yan; Liao, Hong-Li; Liu, Lei; Chen, Ye-Guang; Bierer, Donald; Hu, Hong-Gang; A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/beta-catenin signalling pathway, Chemical Science, 2017,11(8): 7368-7373

9、 Zhao, Bing; Qi, Zhen; Li, Yehua; Wang, Chongkai; Fu, Wei; Chen, Ye-Guang; The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells, Nature Communications, 2015, 6(7166)