Jiang Ren, Ph.D.

Professional Experiences

2021.07-now Research Fellow at the Institute of Biomedical Innovation, Nanchang University.

2021.03-2024.03 Assistant Researcher, The Eighth Affiliated Hospital, Sun Yat-sen University.

2018.092020.12 Post Doc, Leiden University Medical Center.

Education

2014.09-2018.09 Ph.D, Leiden University Medical Center.

2010.09-2013.07 Master, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University.

2006.09-2010.06 Bachelor, Chengdu medical college.

Research Interests

The underlying mechanisms of protein post-translational modifications in cancer and infectious diseases.

Selected Publications

1. Zong Z#, Ren J#, Yang B, Zhang L, Zhou F: Emerging roles of lysine lactyltransferases and lactylation. Nature Cell Biology 2025, 27(4):563-574.

2. Ren J, Liu S, Zhang L. Inhibitor of differentiation 3 confers the robust anti-tumor activity of Kupffer cells. MedComm 2024, 5(9):e708.

3. Ren J#, Wang S#, Zong #Z, Pan T#, Liu S, Mao W, Huang H, Yan X, Yang B, He X*, Zhou F*, Zhang L*. TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence. Nature Communications 2024, 15(1):244.

4. Ren J#, Yu P#, Liu S#, Li R, Niu X, Chen Y, Zhang Z, Zhou F, Zhang L: Deubiquitylating Enzymes in Cancer and Immunity. Advanced Science 2023:e2303807.

5. Ren J#, Zhang Z#, Zong Z, Zhang L, Zhou F: Emerging Implications of Phase Separation in Cancer. Advanced Science 2022:e2202855.

6. Zong Z#, Wei Y#, Ren J#, Zhang L, Zhou F: The intersection of COVID-19 and cancer: signaling pathways and treatment implications. Molecular Cancer 2021, 20:76.

7. Ren J, Wang Y, Ware T, Iaria J, Ten Dijke P, Zhu HJ: Reactivation of BMP signaling by suboptimal concentrations of MEK inhibitor and FK506 reduces organ-specific breast cancer metastasis. Cancer Letters 2020, 493:41-54.

8. Ren J, Smid M, Iaria J, Salvatori DCF, van Dam H, Zhu HJ, Martens JWM, Ten Dijke P: Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression. Breast Cancer Research 2019, 21:109.

9. Sow HS#, Ren J#, Camps M, Ossendorp F, Ten Dijke P: Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models. Cells 2019, 8.

10. Liu S, Ren J, Ten Dijke P: Targeting TGFβ signal transduction for cancer therapy. Signal Transduction and Targeted Therapy 2021, 6:8.

11. Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, et al: Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. PNAS 2020, 117:29684-29690.

12. Sundqvist A, Morikawa M, Ren J, Vasilaki E, Kawasaki N, Kobayashi M, Koinuma D, Aburatani H, Miyazono K, Heldin CH, et al: JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion. Nucleic Acids Research 2018, 46:1180-1195.