Principal Investigator, Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital; School of Basic Medical Sciences; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang 330006, China

haifeng.ye@ncu.edu.cn

Education

2018-2022, Ph.D. Medical Research, Ludwig Maximilian University of Munich, Germany.

2015-2018, M.Sc. Basic Medicine, Jiangxi Medical College, Nanchang University, China. :

2010-2015, B.Sc. Medical Laboratory Science, Jiangxi Medical College, Nanchang University, China.

Professional Experiences

2024-present: Principal Investigator (PI), Professor, Doctoral Supervisor, School of Basic Medical Sciences, Nanchang University, China

2024-present: Principal Investigator (PI), Professor, Doctoral Supervisor, Department of Burns, First Affiliated Hospital of Nanchang University, China

2022-2023: Postdoctoral Researcher, Institute of Regenerative Biology and Medicine, Helmholtz Munich, Germany

Research Interests:

My research focuses on the role of fascia tissue in tissue injury repair, regeneration, and anti-aging. I aim to elucidate novel mechanisms underlying skin scar formation and to identify new therapeutic agents that promote skin wound healing and regeneration, providing new treatment strategies and molecular targets for clinical application. Specifically, my group investigates: 1) The role of fascia mobilization in skin wound healing, including the contributions of fibroblast subpopulations, macrophage extracellular traps, and growth factor signaling (Wnt/β-catenin, IGF1); 2) Mechanisms of scarless versus scar-forming regeneration and how distinct fibroblast assemblies determine healing outcomes; 3) Translational approaches, including biomaterials and drug discovery, for improving skin wound repair and reducing scarring.

Grants

National Natural Science Foundation of China, Young Scientists Fund (Category C), 82402919, "Mechanism of SFRP2 in regulating fascia mobilization via the Wnt/β-catenin signaling pathway in skin wound healing," 2025.01-2027.12, ¥300,000, PI

National Natural Science Foundation of China, General Program, 82572888, "Mechanism of macrophage extracellular traps (METs) in regulating fibroblast spatiotemporal differentiation and fascia mobilization in skin wound healing," 2026.01-2029.12, ¥480,000, PI

Jiangxi Provincial Department of Science and Technology, Natural Science Foundation Youth Program, S20254132, "Mechanism of IGFBP5 in regulating fascia mobilization via the IGF1 signaling pathway in skin wound healing," 2025.06-2027.06, ¥100,000, PI

Organization Department of Jiangxi Provincial Committee, Talent Introduction and Cultivation Program, 2024, ¥100,000, PI

Academic Appointments

Young Editorial Board Member, Burns & Trauma

Young Editorial Board Member, Chinese Journal of Burns and Wound Repair

Youth Committee Member, Burns and Tissue Repair Committee, Cross-Straits Medicine Exchange Association

Council Member, Jiangxi Physiological Society

Council Member, Jiangxi Society for Cell Biology

Member, European Tissue Repair Society (ETRS)

Guest Editor, Medicina (Special Issue: "From Tissue Repair to Tissue Regeneration: Biomaterials, Stem Cells, Drugs and Clinical Interventions")

Review Activities

Bioengineering, International Journal of Molecular Sciences, Cellular and Molecular Biology (CIMB), Medicina, Dermato, Cell and Developmental Biology, Journal of Ovarian Research, European Journal of Medical Research, Reproductive Biology, BMC Pregnancy and Childbirth, BMC Molecular and Cell Biology.

Publications

Haifeng Ye&, Qing Yu&, Alvin John Lee Kim Seong&, Wendan Dong&, Zhenyu Chang, Donovan Correa-Gallegos, Dongsheng Jiang, Ruoxuan Dai, Kenji Schorpp, Kamyar Hadian, Hans-Günther Machens, Yuval Rinkevich*. Distinct Fibroblast Assemblies Establish Scarless Regeneration. Cell Reports, 2025. (IF=6.9, Top )

Yu C, Li Y, Liu Z, Ye W, Wei L, Xu W, Yan L, Ye H*. RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8+ T Cell Infiltration and Enhances Immunotherapy Response. Journal of Cellular and Molecular Medicine, 2025 Oct;29(20):e70915. (IF=4.2)

Correa-Gallegos D#, Ye H#, Dasgupta B#, Sardogan A, Kadri S, Kandi R, Dai R, Lin Y, Kopplin R, Shenai Disha S, Wannemacher J, Ichijo R, Jiang D, Strunz M, Ansari M, Angelidis I, Schiller H, Voltz T, Hans-Günther M, Rinkevich Y*. CD201+ Fascia Progenitors Choreograph Injury Repair. Nature, 2023, 326(7988):792-802. (Co-first author, IF=69.504)

Xu J, Zhang H, Ye H. Research Progress on the Role of Fascia in Skin Wound Healing. Burns & Trauma, 2025 Apr 16;13:tkaf002. (Corresponding author, IF=9.6)

Ye H, Rinkevich Y. Fascia Layer—A Novel Target for the Application of Biomaterials in Skin Wound Healing. International Journal of Molecular Sciences, 2023 Feb 2;24(3):2936. (IF=6.208)

Huang Y, Ye H. Female Germline Stem Cells: Recent Advances, Opportunities, and Challenges to Overcome. Cell Regeneration, 2025 Aug 12;14(1):34. (Corresponding author, IF=4.7)

Correa-Gallegos D#, Jiang D#, Christ S, Ramesh P, Ye H, Wannemacher J, Kalgudde Gopal S, Yu Q, Aichler M, Walch A, Mirastschijski U, Volz T, Rinkevich Y. Patch Repair of Deep Wounds by Mobilized Fascia. Nature, 2019 Dec;576(7786):287-292. (IF=42.778)

Patents

Chen W, Luo T, Chang J, Ye H, Ma J. A Bletilla striata Antioxidant Composite Nanoparticle and Its Preparation Method and Application. CN118490601B, 2024.10.25.