Dr. Chenglu Xiao, Ph.D.

Distinguished Research Fellow, Regenerative Medicine and Developmental Biology

Nanchang University

xiaochenglu@ncu.edu.cn

Education:

2010-2015, Ph.D. Institute of Molecular Medicine, Peking University, Beijing, China.

2007-2010, B.Sc. The Pilot Class in Life Sciences, China Agricultural University, Beijing, China.

Professional Experiences:

2023-present: Distinguished Research Fellow, Institute of Biomedical Innovation, Nanchang University.

2019-2023: Lecturer, College of Veterinary Medicine, China Agricultural University, Beijing, China.

2016-2019: Postdoc, Institute of Molecular Medicine, Peking University, Beijing, China.

2015-2016: Research Assistant, Institute of Molecular Medicine, Peking University, Beijing, China.

Research Interests:

Myocardial infarction poses a serious threat to human life and health. While various clinical treatments can alleviate its symptoms, they are unable to repair dead cardiomyocytes. In contrast, lower vertebrates such as zebrafish and some newborn mammals can regenerate their hearts after injury. Studying the cellular and molecular mechanisms of cardiac regeneration can provide a theoretical basis for repairing cardiac damage in adult organisms. Our laboratory uses zebrafish, mammals and organoids as models to study the molecular mechanisms by which epigenetics, transcription factors and microenvironments regulate cardiac regeneration.

Editorial board:

N/A

Review activities:

N/A

Community services:

Member of the Council, Jiangxi Society for Cell Biology

Selected Publications:

1) Hou JJ1, Song YB1, Xiao CL1, Shen J, Ma XK, Sun YY, Zhou QC, Chiu SC, Xu Y, Wang F, Huang YY, Zhu XJ, Wang JB, Xiong JW. Cloche/Npas4l Is a Pro-regenerative Platelet Factor during Zebrafish Heart Regeneration. Development Cell 2025 Jun 24:S1534-5807(25)00370-3.

2) Xiao CL*, Xiong JW*. DHA, a potentially therapeutic lipid for myocardial infarction. Protein & Cell 2025 Aug 6;17(1):1–4.

3) Xiao CL1, Hou JJ1, Wang F, Song Y, Zheng JY, Luo LF, Wang JB, Ding WQ, Zhu XJ, Xiong JW. Endothelial Brg1 Fine-tunes Notch Signaling during Zebrafish Heart Regeneration. NPJ Regenerative Medicine 2023 Apr 7;8(1):21.

4) Wang MD, Wang D, Lang Y, Shao AW, Zhang R, Tang J, Lai DM*, Xiao CL*. L3MBTL3 Is Induced by HIF-1α and Fine tunes the HIF-1α Degradation under Hypoxia in vitro. Heliyon 2023 Jan 24;9(2):e13222.

5) Xiao CL1, Xiong JW. ERK signaling waves via body-wall muscles guide planarian whole-body regeneration across long distances. Cell Regeneration 2023 Nov 8;12(1):36.

6) Xiao CL1, Wang F, Hou JJ, Zhu X, Xiong JW. Nanoparticle-mediated siRNA Gene-Silencing in Adult Zebrafish Heart. JoVE 2018 Jul 29;(137):58054.

7) Xiao CL1, Gao L1, Hou Y, Xu C, Chang N, Wang F, Hu K, He A, Luo, Y, Wang J, Peng JR, Tang F, Zhu X, and Xiong JW. Chromatin Remodeling Factor Brg1 Regulates Myocardial Proliferation and Regeneration in Zebrafish. Nature Communications 2016 Dec 8;7:13787.