Dr. Ya-Long Wang, Ph.D.

Distinguished Research Fellow of Nanchang University

wangyl_ncu@ncu.edu.cn

Education

 2016.09-2021.06, Ph.D., Biology, School of Life Sciences, Tsinghua University, China

 2012.09-2016.07, B.Sc., Bioengineering, School of Life Sciences, Shanghai University, China

Professional Experiences

 2025.09-present: Research Fellow, Institute of Biomedical Innovation, Nanchang University, China

 2023.08-2025.09: Associate Research Fellow, Guangzhou National Laboratory, China

 2021.08-2023.07: Postdoc, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China

Research Interests:

Research focuses on the establishment of organoid systems and their applications in life and medical research, with core scientific questions covering stem cell fate determination, organ homeostasis regulation, tumor subtyping and pharmacological therapy. Overall, organoid models of colorectal, pancreatic and breast cancers, combined with mouse models, multi-omics technologies and signaling pathway intervention strategies, are adopted to uncover the mechanisms underlying tissue homeostasis maintenance and dysfunction during disease progression, and to further investigate the critical roles of cellular crosstalk and fate regulation in tumor initiation and progression.

Community services

 Deputy Director, National Organoid Resource Repository of Ministry of Education

 Committee Member, Chinese Society for Cell Biology

 Standing Committee Member, China Medicinal Biotechnology Association

 Committee Member, China Standardization Association

 Committee Member, Guangdong Respiratory and Health Society

Selected Publications

1、 Yalong Wang, Ruoyu Lou, Zhe Zhang, Chuyu Xiao, Shicheng Yu, Siting Wei, Yuan Liu, Wei Fu, Baojie Li and Ye-Guang Chen. Stromal BMP signaling regulates mucin production in the large intestine. Science Advances, 2023; 9(43): eadi1827.

2、 Yalong Wang, Wanlu Song, Jilian Wang, Ting Wang, Xiaochen Xiong, Zhen Qi, Wei Fu, Xuerui Yang, Ye-Guang Chen. Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 2020; 217(2): e20191130.

3、 Liansheng Liu, Yalong Wang, Shicheng Yu, Huidong Liu, Yehua Li, Shan Hua and Ye-Guang Chen. Transforming growth factor beta promotes inflammation and tumorigenesis in Smad4-deficient intestinal epithelium in a YAP-dependent manner. Advanced Science, 2023; e2300708.

4、 Yalong Wang, Wanlu Song, Shicheng Yu, Yuan Liu, Ye-Guang Chen. Intestinal cellular heterogeneity and disease development revealed by single-cell technology. Cell Regeneration, 2022; 11(1): 26.

5、 Ruoyu Lou, Wanlu Song, Shicheng Yu, Xiaodan Wang, Yuan Liu, Ye-Guang Chen, Yalong Wang. Identification of feature genes in intestinal epithelial cell types. Cell Regeneration, 2024;13(1):24.

6、 Ronghui Tan, Fan Hong, Ting Wang, Nanshan Zhong, Hongling Zhao, et al., Yalong Wang, Tongbiao Zhao, Ye-Guang Chen. Standard: Human gastric cancer organoids. Cell Regeneration, 2024; 13(1), 33.

7、 Fan Hong, Ronghui Tan, Ting Wang, Nanshan Zhong, Hongling Zhao, et al., Yalong Wang, Tongbiao Zhao, Ye-Guang Chen. Standard: Human gastric organoids. Cell Regeneration, 2025; 14(1), 2.

8、 Yalong Wang, Hanqing Lin, Lianzheng Zhao, Fan Hong, Jie Hao, et al. Standard: Human intestinal organoids. Cell Regeneration, 2023;12(1):23.

9、 Yalong Wang, Ronghui Tan, Ye-Guang Chen. Organoid Culture of Different Intestinal Segments from Human and Mouse. Methods in molecular biology, 2024; Apr, 23.

10、 Hanqing Lin, Yalong Wang, Chunyan Cheng, Yuxin Qian, Jie Hao, et al. Standard: Human intestinal cancer organoids. Cell Regeneration, 2023;12(1):24.

11、 Xin Fu, Qiang He, Yu Tao, Mengdi Wang, Wei Wang, Yalong Wang, Qing Cissy Yu, Fang Zhang, Xiaoyu Zhang, Ye-Guang Chen, Dong Gao, Ping Hu, Lijian Hui, Xiaoqun Wang, Yi Arial Zeng. Recent advances in tissue stem cells. Science China life science, 2021; 64(12):1998-2029.

12、 Zongyao Zheng, Meimei Huang, Yonglong Du, Zhanfa Zhang, Chenming Zeng, Yalong Wang. Advances in skin organoid technology and their applications across biomedical fields: A review. Organoid Research，2025; 1(4): 025320026.