Xueli Bian, Ph.D.

supervisor of Ph.D. student

bianxueli@ncu.edu.cn

Education

● 2012-2018 Ph.D. in Cell Biology, School of Life Sciences, Xiamen University, Xiamen, China.

● 2008-2012 B.E. in Bioengineering, School of Life Sciences, Nanchang University, Nanchang, China.

Professional Experiences

● 2021-Present Distinguished Professor, School of Basic Medical Sciences, Nanchang University.

● 2019–2021 Postdoctoral Fellow, Qingdao Cancer Institute, Qingdao University.

Research Interests

Our mission is to advance the understanding of the function and molecular mechanisms of cell metabolism in tumor development and immune regulation. Combining metabolomics, bioinformatics, and molecular biology techniques, we aim to uncover the mechanisms of post-translational modification, spatiotemporal regulatory networks and non-canonical functions of key metabolic enzymes in tumorigenesis.

Review Activities

Cancer Letters, Cell Communication and Signaling, International Journal of Biological Macromolecules.

Selected Publications

1．Luo, Hongliang, Fenna Zhang, Yingping Li, Rui Tong, Chengchang Gao, Yueqi Wen, and Xueli Bian. "SUMOylation-stabilized G6PD orchestrates metabolic rewiring for oxidative stress survival and chemoresistance in HCC via a PKCδ-phosphorylation trigger." Cell Death & Differentiation (2026): 1-14.

2．Luo, Hongliang, Xiaorui Jin, Chengchang Gao, Qinqin Deng, Linfen Han, Fumin Hu, Rui Tong, Donglin Li, Haoying Yang, and Xueli Bian. "Rottlerin triggers dual degradation of SLC7A11 and GPX4 to drive ferroptosis and chemosensitization in hepatocellular carcinoma." Cell Death Discovery (2026).

3．Li, Yingping, Fenna Zhang, Fumin Hu, Rui Tong, Yueqi Wen, Guokai Fu, and Xueli Bian. "ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation." Cell Death Discovery 11, no. 1 (2025): 266.

4．Bian, Xue-li, Hang-zi Chen, Peng-bo Yang, Ying-ping Li, Fen-na Zhang, Jia-yuan Zhang, Wei-jia Wang et al. "Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation." Nature communications 8, no. 1 (2017): 14420.

5．Bian, Xueli, Rui Liu, Ying Meng, Dongming Xing, Daqian Xu, and Zhimin Lu. "Lipid metabolism and cancer." Journal of Experimental Medicine 218, no. 1 (2020): e20201606.

6．Bian, Xueli, Hongfei Jiang, Ying Meng, Ying-ping Li, Jing Fang, and Zhimin Lu. "Regulation of gene expression by glycolytic and gluconeogenic enzymes." Trends in cell biology 32, no. 9 (2022): 786-799.

7．Hou, Pei-pei, Li-juan Luo, Hang-zi Chen, Qi-tao Chen, Xue-li Bian, Sheng-fu Wu, Jia-xin Zhou et al. "Ectosomal PKM2 promotes HCC by inducing macrophage differentiation and remodeling the tumor microenvironment." Molecular cell 78, no. 6 (2020): 1192-1206.

8．Xu, Daqian, Fei Shao, Xueli Bian, Ying Meng, Tingbo Liang, and Zhimin Lu. "The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies." Cell metabolism 33, no. 1 (2021): 33-50.