Dr. Rongqing Chen, Ph.D.

Dr. Rongqing Chen, Ph.D.

Professor, Neuroscience,

School of Basic Medicine and the First Affiliated Hospital,

Nanchang University,

Ndyfy08211@ncu.edu.cn.

Education

 2011-2014, Ph.D., University of Mainz (Germany).

 2006-2009, M.Sc., Nanjing Medical University.

 1996-2001, B.M., Shandong University.

Professional experiences

 2026-now, Professor, Nanchang University.

 2015-2025, Professor, Southern Medical University.

 2009-2011, Research assistant, LSU Health New Orleans (USA).

Research description

Normal brain functions rely on homeostatic neuroexcitation which refers to the electrical activation of neurons in the brain. Neuroexcitation is dynamically modulated by the relative strength of excitation and inhibition of neuronal intrinsic electrical activation and synaptic activation. Besides, more and more studies suggest that glia cells are not only the passive supporters of neurons, but also active players of neuroexcitation, neurocircuit and neuronal functions, Dysregulation of neuroexcitation leads to Disorder of consciousness, epilepsy, depression, autism, schizophrenia and other neurological or psychiatric disorders. The research in my laboratory focuses on cellular and molecular aspects of neuroexcitation in some neurological and neuropsychiatric disorders.

Selected publications

Liu MQ, Chen Y, Chen R#: Social rank-order stability of mice revealed by a novel food competition paradigm in combination with available space competition paradigms. eLife 2025, 14:RP103748.

Lu H, Zhu Y, Wang X, Wu Z, Xu Z, Chen R#, Guo Y#. Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease. Adv Sci (Weinh). 2026;13:e15138.

Liu M*, Zhu J*, Zheng J, Han X, Jiang L, Tong X, Ke Y, Guo Z, Huang W, Cong J, Liu MQ, Lin S, Zhu S, Mei L, Zhang X, Zhang W, Xin WJ, Zhang Z#, Guo Y#, Chen R#: GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles. Cell reports 2025, 44:115343.

Li X*, Fu Q*, Zhong M*, Long Y, Zhao F, Huang Y, Zhang Z, Wen M, Chen K, Chen R#, Ma X#: Quantitative proteomics of the miR-301a/SOCS3/STAT3 axis reveals underlying autism and anxiety-like behavior. Molecular Therapy-Nucleic Acids, 2024, 35(1):102136.

Liang W*, Hou Y*, Huang W*, Wang Y*, Jiang T, Huang X, Wang Z, Wu F, Zheng J, Zhang J, Ou H, Li S, Ping J, Zhang Y, Ye J, Li Z, Yang Q, Zhang J, Zheng X, Li S, Zhu XH, Chen R#, Zhao C#: Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission. Science advances 2022, 8:eabn7357.

Huang W*, Ke Y*, Zhu J, Liu S, Cong J, Ye H, Guo Y, Wang K, Zhang Z, Meng W, Gao TM, Luhmann HJ, Kilb W#, Chen R#: TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures. Cell reports 2021, 36:109404.

Liu M*, Jiang L*, Wen M, Ke Y, Tong X, Huang W, Chen R#: Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy. American journal of physiology Cell physiology 2020, 319:C605-C10.

Chen R*, Okabe A*, Sun H, Sharopov S, Hanganu-Opatz IL, Kolbaev SN, Fukuda A, Luhmann HJ, Kilb W#: Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus. The Journal of physiology 2014, 592:2153-68.

Chen R*, Zhang J*, Fan N*, Teng ZQ*, Wu Y*, Yang H, Tang YP, Sun H, Song Y, Chen C#: Delta9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell 2013, 155:1154-65.

Chen R*, Zhang J*, Wu Y, Wang D, Feng G, Tang YP, Teng Z, Chen C#: Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Cell reports 2012, 2:1329-39.