Dr. Yanling Fan, M.D.

Dr. Yanling Fan, M.D.

Specially-appointed Researcher

Doctoral Supervisor

Education

2014-2019, M. D. Oncology, Tianjin Medical University, Tianjin, China

2010-2014, B.S. Biotechnology, Binzhou Medical University, Yantai, China

Professional Experiences

2026.06- present，The First Affiliated Hospital, School of Basic Medical Sciences and Institute of Biomedical Innovation, Nanchang University, Specially-appointed Researcher

2025.08-2026.05, Beijing Institute of Genomics, Chinese Academy of Sciences (China National Center for Bioinformation), Associate Researcher

2019.08-2025.07, Beijing Institute of Genomics, Chinese Academy of Sciences (China National Center for Bioinformation), Assistant Researcher

Research Interests

Our laboratory focuses on the aging of the cardiovascular system and associated degenerative diseases. We employ technologies such as human stem cells, non-human primate models, single-cell sequencing, and multi-omics approaches to systematically elucidate the molecular mechanisms of cardiovascular aging in primates and to develop intervention strategies for delaying cardiovascular aging.

Community services

Branch of Chinese Geriatrics Society: Basic and Translational Medicine Chapter

Selected Publications

1. Yanling Fan# (Co-first Author#), Yandong Zheng#, Yiyuan Zhang#, Gang Xu#, Chun Liu#, Jianli Hu, Qianzhao, Shuo Zhang, Shuaiqi Fang, Jinghui Lei, Lan-Zhu Li, Xing Wang, Xi Xu, Cui Wang, Si Wang, Shuai Ma, Moshi Song, Wenjian Jiang, Junming Zhu, Yijia Feng, Jiangang Wang, Ying Yang, Guodong Zhu, Xiao-Li Tian, Hongjia Zhang, Weihong Song, Jiayin Yang, Yan Yao*, Guang-Hui Liu*, Jing Qu*, Weiqi Zhang*. ARID5A Orchestrates Cardiac Aging and Inflammation through MAVS mRNA Stabilization. Nature Cardiovascular Research，2025;4(5):602-623.

2. Yingjie Ding#, Yuesheng Zuo#, Bin Zhang#, Yanling Fan# (Co-first Author#), Gang Xu#, Zhongyi Cheng#, Shuai Ma#, Shuaiqi Fang#, Ao Tian, DanDan Gao, Xi Xu, Qiaoran Wang, Yaobin Jing, Mengmeng Jiang, Muzhao Xiong, Jiaming Li, Zichu Han, Shuhui Sun, Si Wang, Fuchu He, Jiayin Yang*, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*. Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures. Cell, S0092-8674(25)00749-4.

3. Jiale Ping#, Qin Qiao#, Dan-Dan Gao#, Yun Li#, Yanling Fan# (Co-first Author#), Yutong Tian#, Muzhao Xiong#, Quan Zheng#, Beier Jiang#, Jiaming Li, Zheng Huang, Qinxin Tu, Zikai Zheng, Xiaoyong Lu, Yiwen Hu, Yangqing Xu, Xiaoyan Sun, Qiaoran Wang, Liu-Jun Xu, Si-Jia Chen, Qi Wu, Lixiao Liu, Yuesheng Zuo, Shuhui Song, Si Wang, Shuai Ma, Jin-Lin Ye, Cheng-Shui Chen, Jing Qu, Yun-Gui Yang, Lan Jiang, Feng Zhang*, Guang-Hui Liu*, Weiqi Zhang*. Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence. Immunity, 2026;59(4):1039-1057.e11.

4. Si Wang#, Xiaohong Yao#, Shuai Ma#, Yifang Ping#, Yanling Fan# (Co-first Author#), Shuhui Sun#, Zhicheng He#, Yu Shi#, Liang Sun#, Shiqi Xiao#, Moshi Song#, Jun Cai, Jiaming Li, Rui Tang, Liyun Zhao, Chaofu Wang, Qiaoran Wang, Lei Zhao, Huifang Hu, Xindong Liu, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*, Xiu-Wu Bian*. A single-cell transcriptomic landscape of the lungs of patients with COVID-19. Nature Cell Biology, 2021. 23(12): p. 1314-1328.

5. Shuai Ma#, Shuhui Sun#, Jiaming Li#, Yanling Fan# (Co-first Author#), Jing Qu#, Liang Sun#, Si Wang, Yiyuan Zhang, Shanshan Yang, Zunpeng Liu, Zeming Wu, Sheng Zhang, Qiaoran Wang, Aihua Zheng, Shuguang Duo, Yang Yu, Juan Carlos Izpisua Belmonte, Piu Chan, Qi Zhou, Moshi Song*, Weiqi Zhang*, Guang-Hui Liu*. Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research, 2020, 1(1): 1-18.

6. Xiaoyan Sun#, Shanshan Che#, Hengchao Wang#, Yanling Fan# (Co-first Author#), Yingjie Ding, Ansheng Tan, Kuan Yang, Jianli Hu, Yixin Zhang, Miyang Ma, Jinghao Hu, Shuhui Sun, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*. Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging. Developmental cell, 2025. S1534-5807(25)00690-2.

7. Yun Li#, Zheng Huang#, Lubin Xu#, Yanling Fan# Co-first Author#) , Jun Ping#, Guochao Li, Yanjie Chen, Chengwei Yu, Qifei Wang, Turun Song, Tao Lin, Mengmeng Liu, Yangqing Xu, Na Ai, Xini Meng, Qin Qiao, Hongbin Ji, Zhen Qin, Shuo Jin, Nan Jiang, Minxian Wang, Shaokun Shu*, Feng Zhang*, Weiqi Zhang*, Guang-Hui Liu*, Limeng Chen*, Lan Jiang*. UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing. Nature Methods. 2025 Jun;22(6):1199-1212.

8. Jiaming Li#, Muzhao Xiong#, Xiang-Hong Fu#, Yanling Fan# (Co-first Author#), Chen Dong#, Xiaoyan Sun, Fang Zheng, Si-Wei Wang, Lixiao Liu, Ming Xu, Cui Wang, Jiale Ping, Shanshan Che, Qiaoran Wang, Kuan Yang, Yuesheng Zuo, Xiaoyong Lu, Zikai Zheng, Tian Lan, Si Wang, Shuai Ma, Shuhui Sun, Bin Zhang, Chen-Shui Chen, Ke-Yun Cheng, Jinlin Ye, Jing Qu, Yongbiao Xue, Yun-Gui Yang*, Feng Zhang*, Weiqi Zhang*, Guang-Hui Liu*.Determining a multimodal aging clock in a cohort of Chinese women. Med. 2023, S2666-6340(23)00197-6.

9. Fang Wang#, Weiqi Zhang#, Qiaoyan Yang#, Yu Kang#, Yanling Fan# (Co-first Author#), Jingkuan Wei, Zunpeng Liu, Shaoxing Dai, Hao Li, Zifan Li, Lizhu Xu, Chu Chu, Jing Qu, Chenyang Si, Weizhi Ji*, Guang-Hui Liu*, Chengzu Long*, Yuyu Niu*. Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein & Cell, 2020, 11(11), 809–824. (Cover story)

10. Xiaoqian Liu#, Zunpeng Liu#, Zeming Wu#, Jie Ren, Yanling Fan, Liang Sun, Gang Cao, Yuyu Niu, Baohu Zhang, Qianzhao Ji, Xiaoyu Jiang, Cui Wang, Qiaoran Wang, Zhejun Ji, Lanzhu Li, Concepcion Rodriguez Esteban, Kaowen Yan, Wei Li, Yusheng Cai, Si Wang, Aihua Zheng, Yong E Zhang, Shengjun Tan, Yingao Cai, Moshi Song, Falong Lu, Fuchou Tang, Weizhi Ji, Qi Zhou, Juan Carlos Izpisua Belmonte*, Weiqi Zhang*, Jing Qu*, Guang-Hui Liu*. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell, 2023, 186(2), 287–304.e26.