Prof. Jinsong Wei

Date of birth：06/26/1991 Gender：Male Birthplace：Bengbu Anhui

Correspondence：No. 999 Xuefu Avenue, Honggutan District, Nanchang City, Jiangxi Province, 330036, China

Tel：(86) 152-1669-5512 E-mail：jinsong.wei@ncu.edu.cn

Education & Training

06/2025~Now, Principal Investigator, Doctoral Supervisor, Institute of Biological Innovation/ School of Basic Medical Sciences, Nanchang University

08/2023~05/2025, Research Associate, Department of Clinical Laboratory, The Tenth People's Hospital Affiliated to Tongji University

07/2021~07/2023, Postdoc, Fudan University & Greater Bay Area Institute of Precision Medicine

07/2017~06/2021, Ph.D. in Genetics, College of Life Science, Fudan University

07/2015~06/2017, Technical Account Manager, GenScript Biotech

09/2013~06/2015, Master in Biochemistry and Molecular Biology, College of Life Science, Northwest Agricultural and Forestry University

09/2009~06/2013, Bachelor in Bio-technology, Innovation Experimental College, Northwest Agricultural and Forestry University

Research Focus

Constructing of human-derived organoids and innovative mouse disease models, in order to develop new drug targets and therapeutic strategies. Exploring pharmacological mechanisms through integrative in vivo and in vitro approaches, with special focus on liver disease modeling and mechanistic researches. In the past five years, as the first author (including co-first author), publishing a series of research papers in Nature Chemical Biology, Journal of Biological Chemistry, Protein & Cell, Genome Biology, Advanced Science, and Chemical Engineering Journal. Leading the National Natural Science Foundation of China (NSFC) and Provincial Natural Science Foundation Frontier Technology Project.

Selected publications (First author)

 Wei, J. #, Cao, Z. #, Li, Q., Li, X., Wang, Q., Zhang, Y., Zhang, R., Wu, X., Dai, Q., Li, X., Sun, F., Zhou, Z., Jiao, S. and Zhao, B. Nuclear ubiquitination permits Hippo-YAP signal for liver development and tumorigenesis. Nature Chemical Biology (IF=14.7) 10.1038/s41589-025-01901-8

 Wei, J. #, Ran, G. #, Wang, X., Jiang, N., Liang, J., Lin, X., Ling, C., and Zhao, B. (2019) Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. Journal of Biological Chemistry (Nature Index, IF=4.8), 294, 14096-14104.

 Yu, C. #, Wan, X. #, Wei, J. #(co-first), et. al and Zhao, B. (2025) Human meibomian gland organoids to study epithelial homeostasis and dysfunction. Protein & Cell

 Liang J. #, Wei J. #(co-first), Cao J#., Qian J., Gao R., Li X., Wang D., Gu Y., Dong L, Yu J., Zhao B., Wang X. (2023) In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation. Genome Biology (IF=16.5), 24, 251

 Liu, G.#, Wei, J.#(co-first), Li, X., Tian, M., Wang, Z., Shen, C., Sun, W., Li, C., Li, X., Lv, E., Tian, S., Wang, J., Xu, S., and Zhao, B. (2022) Near-Infrared-Responded High Sensitivity Nanoprobe for Steady and Visualized Detection of Albumin in Hepatic Organoids and Mouse Liver. Advanced Science (IF=16.3), 9, e2202505

 Tian, M. #, Wei, J. #(co-first), Lv, E. #, Li, C., Liu, G., Wang, Q., Shen, C., Man, B., Wang, J., Zhao, B. and Xu, S. (2024) Drug evaluation platform based on non-destructive and real-time in situ organoid fate state monitoring by graphene field-effect transistor. Chemical Engineering Journal (IF=13.2), 498, 155355

 Wei, J., Zhang, W., and Zhao, B. (2023) Human liver organoid: modeling liver steatosis and beyond. Cell Regeneration (Review, IF=4.0), 12, 17

 Wei, J., Zhang, Y., Knapp, P. E., and Zhao, T. (2016) HIV-1 Tat regulates the expression of the dcw operon and stimulates the proliferation of bacteria. Microbial Pathogenesis (IF=3.6) 90, 34-40.

Grants

 Provincial Natural Science Foundation Frontier Technology Project. No. 20253BAC260011, Human Liver Organoids Reveals Cell Fate Regulation in Liver Diseases, 2025.10-2028.10. Ongoing, Principal Investigator

 National Natural Science Foundation of China (NSFC) for Young Scientists, No. 32400573, Nuclear E3 ligase Ubr5 regulates intrahepatic biliary system formation through Hippo signaling，2025.01 - 2027.12，ongoing, Principal Investigator

 National Natural Science Foundation of China (NSFC) for Excellent Young Scientist，32022022，Signal transduction and adult stem cell fate determination，2021.01-2023.12，completed，Key Participant

 National Key Research and Development Program of China，YS2018YFA010129，The mechanism of chromatin remodeling in liver cell fate determination，2018.07-2022.12，completed，Key Participant

Awards and Honors

 2019/06 Fudan University Roche Diagnostics Scholarship

 2018/06 Fudan University Wu Zhang Lingzhao Scholarship

Personal Interests

 Committed to conducting original and interdisciplinary scientific research

 Chen-style Tai Chi, Calligraphy