Dr. Zheng Wang, Ph.D.

Professor, Cell Biology

Nanchang University

wz1103@ncu.edu.cn

Education

2008 - 2014, Ph.D., College of Life Science, Nankai University, Tianjin, China

2004 - 2008, B.S., School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

Professional experience

2024 - present, Professor, School of Basic Medical Sciences, The Second Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China

2017 - 2024, Associate Investigator, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

2014 - 2017, Postdoctoral fellow, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Research interest

(1) Biological phase separation and transition:

The physiological functions and underlying mechanisms of phase separated biological condensates mediated by their material properties; physiological behaviors and functions mediated by the interface of biological condensates; intervention of the biological pathways and relevant diseases based on biological condensates.

(2) The autophagy-lysosome pathway:

The transcriptional regulation of the autophagy-lysosome pathway; the mechanism of autophagosome maturation; intervention of the autophagy-lysosome pathway and relevant diseases.

Review activities

Nature Communications, Advanced Science, Journal of Cell Biology, Autophagy,

Trends in Biochemical Sciences, Journal of Molecular Biology, Science China Life Sciences, iScience, International Journal of Biological Macromolecules

Selected Publications

(1) Zheng Wang#, and Hong Zhang#. Phase-separated condensates in autophagosome formation and autophagy regulation. (2025) Journal of Molecular Biology, 437: 168964. (第一作者，共同通讯作者).

(2) Zheng Wang*#, Chun Yang*, Dongshi Guan, Jiaqi Li, and Hong Zhang. (2023) Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates. Developmental Cell, 58(11), 919-932. (Featured article and highlighted by Rohit V. Pappu in Developmental Cell entitled “Soaping up transcriptional condensates”). (Corresponding author, co-first author).

(3) Zheng Wang, Di Chen, Dongshi Guan, Xiaobo Liang, Jianfeng Xue, Hongyu Zhao, Guangtao Song, Jizhong Lou, Yan He, and Hong Zhang#. (2022) Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway. Journal of Cell Biology, 221(5): e202112024. (First author).

(4) Zheng Wang#, Jizhong Lou#, and Hong Zhang#. (2022) Essence determines phenomenon: Assaying the material properties of biological condensates. Journal of Biological Chemistry, 298(4):101782. (Co-corresponding author).

(5) Zheng Wang, Gangming Zhang, and Hong Zhang#. (2019) Protocol for analyzing protein liquid–liquid phase separation. Biophysics Reports, 5(1): 1-9. (First author).

(6) Zheng Wang, and Hong Zhang#. (2019) Phase separation, transition, and autophagic degradation of proteins in development and pathogenesis. Trends in Cell Biology, 29(5): 417-427. (Cover story). (First author).

(7) Zheng Wang*, Guangyan Miao*, Xue Xue*, Xiangyang Guo, Chongzhen Yuan, Zhaoyu Wang, Gangming Zhang, Yingyu Chen, Du Feng, Junjie Hu, and Hong Zhang#. (2016) The Vici syndrome protein EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. Molecular Cell, 63(5): 781-795. (Recommended as a “very good” “new finding” in “Faculty of 1000”). (co-first author).

(8) Zheng Wang*, Xue Yang*, Shuang Guo, Yin Yang, Xun-Cheng Su, Yuequan Shen#, and Jiafu Long#. (2014) Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. Journal of Biological Chemistry, 289(40): 27376-27385. (co-first author).

(9) Zheng Wang*, Xue Yang*, Xinlei Chu, Jinxiu Zhang, Hao Zhou, Yuequan Shen#, and Jiafu Long#. (2012) The structural basis for the oligomerization of the N-terminal domain of SATB1. Nucleic Acids Research, 40(9): 4193-4202. (co-first author).