Dr. Bing-Xing Pan, Ph.D.

Professor, Neuroscience

Acting Direction, School of Medicine,

Director, Institute of Life Science

Chief, Laboratory of Fear and Anxiety Disorders

Nanchang University

panbingxing@ncu.edu.cn

Education

 2001-2004, Ph. D. Basic Medicine, Department of Pathophysiology, First Military Medical University, Guangzhou, China.

 1998-2001, M.Sc. Neurophysiology, Department of Physiology, First Military Medical University, Guangzhou, China.

 1993-1998, B.Sc. Clinical Medicine, First Military Medical University, Guangzhou, China

Professional Experiences

 2010-present: Professor, Chief of Laboratory of Fear & Anxiety Disorders, Institute of Life Science, Nanchang University, China

 2005-2010: Postdoc in Unit of Behavior Genetics, NIMH, NIH, USA

 2004-2005: Instructor, Department of Pathophysiology, Southern Medical University, China.

Research Interests:

The research in my lab is focused on dissecting the circuit and synaptic underlying of anxiety and anxiety disorders by prolonged stress exposure. Specifically, we are using combined approaches of multi-omics, optogenetics, fiber photometry, behavior and electrophysiology to address the following scientific questions, 1) The circuit, molecular and synaptic mechanisms underlying the long-lasting disinhibition of amygdala by chronic stress exposure, a kernel brain region responsible for the expression fear and anxiety; 2) The structural and functional bases for the impaired prefrontal control of amygdala activity subsequent to stress exposure; 3) Find approaches to prevent and treat stress-associated anxiety disorder.

Editorial board

• Neuroscience & Biobehavioral Review

• Frontiers in Neuroscience

• Genes, Brain & Behavior;

• Stress & Brain

Review activities

• Neuron, Nature Communications, Science Advances, Plos Biology, Biological Psychiatry, Journal of Neuroscience, Neuroscience Bulletin, Neuropsychopharmacology, Cerebral Cortex.

Community services

• Chinese Neuroscience Society,

• Chinese Pharmacological Society

• Chinese Association for Physiological Science

Selected Publications

1. Wei-Zhu Liu, Shou-He Huang, Yu Wang, Chun-Yan Wang, Han-Qing Pan, Ke Zhao, Ping Hu, Bing-Xing Pan, Wen-Hua Zhang. Medial prefrontal cortex input to basolateral amygdala controls acute stress-induced short-term anxiety-like behavior in mice. Neuropsychopharmacology, 2023, 48:734-744.

2. Dong Lin#, Lu-Hui Li#, Wen-Bing Chen#, Jiang Chen, Dong-Yan Ren, Zhi-Heng Zheng, Chang-Qin Zhao, Yan-Zi Zhong, Bin Luo, Hong-Yang Jing, Peng Chen, Su-Qi Zou, Xin-Sheng Lai, Tian Zhou, Ning Ding, Lei Li, Bing-Xing Pan, Er-Kang Fei. LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity. Molecular Psychiatry, 2023, 28:908–918. (Image, LHPP expression in neurons, Molecular Psychiatry, 2023, 28:517）

3. Xia Qin, Han-Qing Pan, Shou-He Huang, Jia-Xin Zou, Zhi-Heng Zheng, Xiao-Xuan Liu, Wen-Jie You, Zhi-Peng Liu, Jun-Li Cao, Wen-Hua Zhang, Bing-Xing Pan. GABAA(δ) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety. Science Bulletin, 2022, 67:97-110.

4. Han-Qing Pan, Xiao-Xuan Liu, Ye He, Jin Zhou, Cai-Zhi Liao, Wen-Jie You, Si-Ying Jiang, Xia Qin, Wen-Bing Chen, Er-Kang Fei, Wen-Hua Zhang, Bing-Xing Pan. Prefrontal GABAA(δ)R promotes fear extinction through enabling the plastic regulation of neuronal intrinsic excitability. Journal of Neuroscience, 2022, 42(29):5755-5770. (Featured Article)

5. Peng Chen#, Zi-Yang Liu#, Qian Zhang, Dong Lin, Song Lu, Jiang-Hong Liu, Hui-Feng Jiao, Xin-Sheng Lai, Su-Qi Zou, Shun-Qi Wang, Tian Zhou, Bao-Ming Li, Li Zhu*, Bing-Xing Pan, Er-Kang Fei*. DSCAM deficiency leads to premature spine maturation and autism-like behaviors. Journal of Neuroscience, 2022, 42(4):532-551.

6. Xia Qin, Han-Qing Pan, Shou-He Huang, Jia-Xin Zou, Zhi-Heng Zheng, Xiao-Xuan Liu, Wen-Jie You, Zhi-Peng Liu, Jun-Li Cao, Wen-Hua Zhang, Bing-Xing Pan. GABAA(δ) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety. Science Bulletin, 2022, 67:97-110.

7. Wen-Hua Zhang, Jun-Yu Zhang, Andrew Holmes, Bing-Xing Pan. Amygdala circuit substrates for stress adaptation and adversity. Biological Psychiatry, 2021, 89:847-856. (Cover) (Invited Review)

8. Wei-Zhu Liu#, Wen-Hua Zhang#, Zhi-Heng Zheng, Jia-Xin Zou, Xiao-Xuan Liu, Shou-He Huang, Wen-Jie You, Ye He, Jun-Yu Zhang, Xiao-Dong Wang, Bing-Xing Pan. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nature Communications, 2020, 11:2221.

9. Wen-Hua Zhang, Wei-Zhu Liu, Ye He, Wen-Jie You, Jun-Yu Zhang, Hong Xu, Xiao-Li Tian, Bao-Ming Li, Lin Mei, Andrew Holmes, Bing-Xing Pan. Chronic stress causes projection-specific adaptation of amygdala neurons via small-conductance calcium-activated potassium channel downregulation. Biological Psychiatry, 2019, 85:812-828. (Commentary by C. Morel, S. Montgomery, M.H Han, Small-Conductance, Calcium-Activated Potassium Channels: A Key Circuit Determinant for Stress-Induced Amygdala Dysfunction. Biological Psychiatry, 2019, 85:784-786)

10. Jun-Yu Zhang#, Tao-Hui Liu#, Ye He, Han-Qing Pan, Wen-Hua Zhang, Xiao-Li Tian, Xiao-Ping Yin, Bao-Ming Li, Xiao-Dong Wang, Andrew Holmes, Ti-Fei Yuan, Bing-Xing Pan. Chronic stress remodels synapses in an amygdala circuit-specific manner. Biological Psychiatry, 2019, 85:189-201. (Commentary by G. Treccani, From Structure to Behavior: Circuit Specificity of Stress-Induced Synaptic Plasticity in the Basolateral Amygdala Projection Neurons. Biological Psychiatry, 2019, 85:e7-e9.)

11. Zhi-Peng Liu#, Qing-Hai He#, Han-Qing Pan, Jin Zhou, Ye He, Xiao-Bin Xu, Xiao-Ping Yin, Bao-Ming Li, Tian-Ming Gao*, Bing-Xing Pan*. Delta subunit containing GABAA receptors disinhibit lateral amygdala and facilitate fear learning in mice. Biological Psychiatry. 2017, 81(12): 990-1002.