I obtained my PhD degree in biophysics from Nagoya University in Japan in 2012. After my PhD, I worked as a postdoctoral researcher from 2012 to 2014 at Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Subsequently, I served as a postdoctoral fellow in the Harvard Medical School from 2014 to 2017. Since July 2017, I have been working as the professor at the School of Basic Medical Sciences of Nanchang University.

Our lab is devoted to the study of structure and drug discovery and development of membrane proteins related to human diseases. With a focus on neuropsychiatric diseases, cardiovascular and tumor, which pose serious threats to the health and well-being of the Chinese people, drug developments for anti-depression, the prevention of stroke and anti-tumor are being conducted on the basis of three-dimensional structures of ion channels and G-protein coupled receptors. Our work has been featured in peer-reviewed journals such as Nature (2 articles), PNAS (2 articles), Science Advances, Nature Communications, Science Bulletin, JBC, JMB and JVI.

1. Li, J.; Lin, C.; Zhou, X.; Zhong, F.; Zeng, P.; McCormick, P. J.; Jiang, H#.; Zhang, J#., Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814. J Mol Biol 2022, 434 (16), 167706.

2. Li, J.; Lin, C.; Zhou, X.; Zhong, F.; Zeng, P.; Yang, Y.; Zhang, Y.; Yu, B.; Fan, X.; McCormick, P. J.; Fu, R.; Fu, Y.; Jiang, H#.; Zhang, J#., Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. J Virol 2022, 96 (8), e0201321.

3. Song, X.; Li, J.; Tian, M.; Zhu, H.; Hu, X.; Zhang, Y.; Cao, Y.; Ye, H.; McCormick, P. J.; Zeng, B.; Fu, Y#.; Duan, J#.; Zhang, J#., Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem 2022, 298 (2), 101487.

4. Zhang, Y.; Gao, H.; Hu, X.; Wang, Q.; Zhong, F.; Zhou, X.; Lin, C.; Yang, Y.; Wei, J.; Du, W.; Huang, H.; Zhou, H.; He, W.; Zhang, H.; Zhang, Y.; McCormick, P. J.; Fu, J.; Wang, D.; Fu, Y.; Lu, X.; Zhang, T.; Duan, J.; Qin, B.; Jiang, H.; Luo, J.; Zhang, Y.; Chen, Q.; Luo, Q.; Cheng, L.; Zhang, Z.; Zhang, J#.; Li, J#., Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J Virol 2022, 96 (1), e0125321.

5. Li, J.; Zhou, X.; Zhang, Y.; Zhong, F.; Lin, C.; McCormick, P. J.; Jiang, F.; Luo, J.; Zhou, H.; Wang, Q.; Fu, Y.; Duan, J.; Zhang, J#., Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode. Sci Bull (Beijing) 2021, 66 (7), 661-663. (# 通讯作者)

6. Duan J, Li J, GL Chen, X Peng, Y Zhang, JB Wang, Clapham DE, B Zeng#, Li Z#, Zhang J#. (2019). Cryo-EM structure of TRPC5 at 2.8 Å resolution reveals unique and conserved structural elements essential for channel function. Science Advances Jul 24;5(7):eaaw7935 (# 通讯作者)

7. Duan J, Li J, B Zeng, GL Chen, X Peng, Y Zhang, JB Wang, Clapham DE, Li Z#, Zhang J#. (2018). Structure of the mouse TRPC4 ion channel. Nature Communications Aug 6;9(1):3102. (# 通讯作者)（IF:12.121）

8. Duan J, Li Z, Li J, Hulse R, Santa-Cruz A, Valinsky W, Abiria S, Krapivinsky G, Zhang J#, Clapham DE#. (2018). Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc Natl Acad Sci U S A Aug 28;115(35):E8201-E8210. (# 通讯作者) （IF:9.412）

9. Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J#, Clapham DE#. (2018). Structure of full-length human TRPM4. Proc Natl Acad Sci U S A 115: 2377-82 (# 通讯作者) （IF:9.412）

10. Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE. (2018). Cryo-EM structure of the polycystin 2-l1 ion channel. Elife 7 （IF:7.551）

11. Chen, J., Fu, Y., Day, D. S., Sun, Y., Wang, S., Liang, X., Gu, F., Zhang, F., Stevens, S. M., Zhou, P., Li, K., Zhang, Y., Lin, R. Z., Smith, L. E. H., Zhang, J., Sun, K., Melero-Martin, J. M., Han, Z., Park, P. J., Zhang, B., Pu, W. T. (2017). VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nature Communications. 81, 383（IF:11.878）

12. Abiria, S. A., Krapivinsky, G., Sah, R.,Santa-Cruz, A. G.,Chaudhuri, D., Zhang, J., Adstamongkonkul, P., DeCaen, P. G., Clapham, D. E. (2017). TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles. Proc Natl Acad Sci, 114, 30, E6079-E6088 （IF:9.580）

13. Lin, Z., Guo, H., Cao, Y., Zohrabian, S., Zhou, P., Ma, Q., VanDusen, N., Guo, Y., Zhang, J., Stevens, S.M., et al. (2016). Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. （IF:9.190）

14. Zhang, J*., Zhang, K*., Gao, Z.G., Paoletta S., Zhang, D., Han, G.W., Li T., Ma L., Zhang W., Müller C.E., Yang H., Jiang H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu B., and Zhao Q. (2014). Agonist-bound structure of the human P2Y12 receptor. Nature, 509, 119-22. (*equally contributed to the work) （IF:43.070）

15. Zhang, K*., Zhang, J*., Gao, Z.-G., Zhang, D., Zhu, L., Han, G.W., Moss, S.M., Paoletta, S., Kiselev, E., Lu, W., et al. (2014). Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature, 509, 115-8. (*equally contributed to the work) (IF:43.070）

1. Overseas High Level Talents" Youth Project, year 2017, 2 million，principal investigator.

2. Jiangxi Provincial Special Fund for Talent Development, year 2017, 5 million yuan, principal investigator.

3. The National Natural Science Foundation of China "Research on the Structure and Function of Mammalian Transient Receptor Potential Ion channel TRPM7",2018,0.6 million,principal investigator.

4. Key Project of Jiangxi Natural Science Foundation “Three dimensional structure analysis of human magnesium Ion channel protein TRPM6 and its binding mechanism with magnesium ion”,2018, 0.5 million,principal investigator.

5. The National Natural Science Foundation of China "structural pharmacology research on TRPC5 Ion channel, a new antidepressant target",2020,0.55 million,principal investigator.

6. The first prize of Jiangxi Provincial Natural Science Award in 2020 (ranking first), "Structure and Drug development of purinergic receptor P2Y12, the target of antithrombotic drugs"

Tel：17379008951

E-mail: zhangxiaokong@hotmail.com

Wechat：zhangjin389575