Xueli Bian Lab

Principle Investigator

Dr. Xueli Bian，supervisor of master student

Distinguished Professor of Nanchang University

Professor Xueli Bian graduated from Nanchang University with a bachelor's degree in 2012 and a PHD in Xiamen University in 2018. He has completed postdoctoral training at Qingdao Cancer Institute in 2021. Currently he is a distinguished professor of Nanchang University and won Jiangxi Provincial Fund for Distinguished Young Scholars in 2022. His research interest focus on protein post-translational modification on metabolic homeostasis and tumor development, he has published many papers in authoritative journals such as Nature Communications, Molecular Cell, Journal of Experimental Medicine, Cell Metabolism, Trends in Cell Biology.

Research Directions

Our group mission is to advance understanding of the function and molecular mechanism of cell metabolism in tumor development and immune regulation. Combined with metabolomics, bioinformatics and molecular biology technology, we aim to uncover the mechanism of post-translational modification, spatiotemporal regulatory network and non-canonical functions of key metabolic enzymes in tumorigenesis.

Lab member

Dr. Bolei Dai, Lecturer

Dr. Bolei Dai graduated from Huazhong University of Science and Technology with a bachelor's degree in 2014 and a PHD in 2022. As the first author (including co-first author), he has published 2 papers in Theranostics and Nanophotonics. He has obtained 1 utility model patent and applied for 3 national patents. In 2022, he joined Professor Xueli Bian's team in the Institute of Biomedicine, Nanchang University. His future research directions include: 1. To establish in vivo optical imaging methods and develop tumor molecular probes, and to study basic medical problems visually. 2. Tumor immunotherapy combined with tumor metabolic characteristics.

Selected Publications

1． Bian XL#, Chen HZ#, Yang PB#, Li YP#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420.

2．Bian XL#, Liu R#, Meng Y#, Xing DM*, Xu DQ*, & Lu ZM*. Lipid metabolism and cancer[J]. Journal of Experimental Medicine, 2021, 218(1).

3．Xu D#, Shao F#, Bian XL#, Meng Y, Liang TB, Lu ZM*. The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies[J]. Cell Metabolism, 2021, 33(1): 33-50.

4．Hou PP#, Luo LJ#, Chen HZ#, Chen QT#, Bian XL#, Wu SF, Zhou JZ, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen QH, Zhou DW, Wu Q*. Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment. MOLECULAR CELL. 2020 May 20;S1097-2765(20)30305-1.

5．Shao F#, Bian XL#, Jiang HF, Zhao GX, Zhu L, Xu DQ,Wang S, Guo W, Xing DM, Xue Q, Gao YB*, He J*, Lu ZM*. Association of phosphoenolpyruvate carboxykinase 1 protein kinase activity-dependent sterol regulatory element-binding protein 1 activation with prognosis of oesophageal carcinoma[J]. European Journal of Cancer, 2021, 142: 123-131.

6．Bian, X. #, Jiang, H. #, Meng, Y. #, Li, Y. P. #, Fang, J. *, & Lu, Z. *. Regulation of gene expression by glycolytic and gluconeogenic enzymes[J]. Trends in Cell Biology, 2022.

7．Dai BL#, Zhang R#, Qi SH*, Liu L, Zhang X, Deng DQ, Zhang J, Xu YL, Liu FX, Liu Z, Luo QM, Zhang ZH*. Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens. Theranostics, 2022; 12(17): 7603-7623.

8．Deng DQ#, Dai BL#, Wei JS, Yuan XN, Yang XQ, Qi SH*, Zhang ZH*. A drawer-type abdominal window with an acrylic/resin coverslip enables long-term intravital fluorescence/photoacoustic imaging of the liver. Nanophotonics, 2021, 10(12): 3369-3381.

Grants Approved

2. The 66th batch of general first-class grants from the China Postdoctoral Foundation：Role of CHKα2 in the lipolysis of lipid droplets in cancer cells（2019M660160，2019.1210-2021.06）

E-mail：bianxueli@ncu.edu.cn

office：Room 416, the fourth experimental building of Medical College of Nanchang University, No. 1299, Xuefu Avenue, Honggutan District, Nanchang City.

Phone number：17750667096